Decreased cardiac mortality with nicorandil in patients with ischemic heart failure

نویسندگان

  • Akiomi Yoshihisa
  • Yu Sato
  • Shunsuke Watanabe
  • Tetsuro Yokokawa
  • Takamasa Sato
  • Satoshi Suzuki
  • Masayoshi Oikawa
  • Atsushi Kobayashi
  • Yasuchika Takeishi
چکیده

BACKGROUND Effective treatments in heart failure (HF) patients with ischemic etiology have not been fully established. Nicorandil, combination of nitrate component and sarcolemmal adenosine triphosphate-sensitive potassium channel opener, is a potent vasodilator of coronary and peripheral vessels and has been used as an antianginal agent. Therefore, we examined impacts of nicorandil on cardiac mortality in ischemic HF patients. METHODS Consecutive 334 HF patients with ischemic etiology were retrospectively registered and divided into 2 groups based on oral administration of nicorandil: nicorandil group (n = 116) and non-nicorandil group (n = 218). We retrospectively examined cardiac mortality. RESULTS In the Kaplan-Meier analysis (mean follow-up period 963 days), cardiac mortality was significantly lower in the nicorandil group than in the non-nicorandil group (11.2% vs. 19.7%, P = 0.032). In the Cox proportional hazard analysis, usage of nicorandil was a suppressor of cardiac mortality (hazard ratio 0.512, 95% confidence interval 0.275-0.953, P = 0.035), and this result was consistent in several subgroup analyses, such as left ventricular ejection fraction, percutaneous coronary intervention, coronary artery bypass graft, diabetes, β-blockers, and statins. CONCLUSION Nicorandil is potentially effective for reducing mortality in patients with ischemic heart failure. TRIAL REGISTRATION This was a retrospective study.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of transesophageal echocardiography in detecting cardiac sources of emboli in ischemic stroke patients

  Background: Embolus is one of the causes of ischemic stroke that can be due to cardiac sources such as valvular heart diseases and atrial fibrillation and atheroma of the aorta. Transesophageal echocardiography (TEE) is superior in identifying potential cardiac sources of emboli. Due to insufficient data on TEE findings in ischemic stroke in Iran, the present study was done to evaluate TEE in...

متن کامل

Evaluation of Cardiac Mitochondrial Function by a Nuclear Imaging Technique using Technetium-99m-MIBI Uptake Kinetics

Mitochondria play an important role in energy production for the cell. The proper function of a myocardial cell largely depends on the functional capacity of the mitochondria.  Therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. Although originally designed for evaluating myocardial perfusion, 99mTc...

متن کامل

Correlation between low T3 syndrome and mortality rate in patients with systolic heart failure

Introduction: This study was performed to evaluate the prevalence of low T3 syndrome among patients with heart failure and to assess the correlation between decreased level of tri iodothyronin (T3) with mortality rate. Methods: In a prospective cross-sectional study, 91 patients with systolic heart failure were admitted to Mohammadi hospital in Bandar Abbas in 2008.Thyroid function test w...

متن کامل

Comparison of Vitamin D Serum Level in Patients with Cardiac Ischemic and Control Group at the Heart Hospital of Hamadan City

Introduction: During the recent years, vitamin D deficiency was determined as a risk factor for cardiovascular diseases. The purpose of this study was to evaluate the association of vitamin D with ischemic heart disease in the city of Hamadan. Methods: A case control-study was performed with 72 patients with ischemic heart disease, which had been confirmed by angiography in the case group. V...

متن کامل

ریسک فاکتورهای مرگ بعد از عمل Coronary artery bypass graft بیمارستان امام، 78-1375

Introduction: Ischemic heart disease is the most common cause of mortality in developed countries. CABG (Coronary Artery Bypass Graft) is one of the therapeutic methods in ischemic heart disease. Methods and Materials: Considering the increased incidence of coronary artery disease in Iran, and with increased rate of CABG, we performed a cross sectioned study (1996-1999). In 635 patients 467 mal...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2017